VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
Identifieur interne : 001634 ( Main/Exploration ); précédent : 001633; suivant : 001635VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
Auteurs : Harri Nurmi ; Pipsa Saharinen ; Georgia Zarkada ; Wei Zheng ; Marius R. Robciuc ; Kari Alitalo [Finlande]Source :
- EMBO Molecular Medicine [ 1757-4676 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Facteur de croissance endothéliale vasculaire de type C.
- métabolisme : Facteur de croissance endothéliale vasculaire de type C.
- physiologie : Intestins, Vaisseaux lymphatiques.
- Animaux, Délétion de gène, Métabolisme des lipides, Souris, Souris knockout.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C.
- chemical , metabolism : Vascular Endothelial Growth Factor C.
- physiology : Intestines, Lymphatic Vessels.
- Animals, Gene Deletion, Lipid Metabolism, Mice, Mice, Knockout.
Abstract
Vascular endothelial growth factor C (VEGF-C) binding to its tyrosine kinase receptor VEGFR-3 drives lymphatic vessel growth during development and in pathological processes. Although the VEGF-C/VEGFR-3 pathway provides a target for treatment of cancer and lymphedema, the physiological functions of VEGF-C in adult vasculature are unknown. We show here that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine. Following
Url:
DOI: 10.15252/emmm.201505731
PubMed: 26459520
PubMed Central: 4644375
Affiliations:
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Robciuc</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><nlm:aff id="au1"></nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26459520</idno><idno type="pmc">4644375</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644375</idno><idno type="RBID">PMC:4644375</idno><idno type="doi">10.15252/emmm.201505731</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000331</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000331</idno><idno type="wicri:Area/Pmc/Curation">000331</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000331</idno><idno type="wicri:Area/Pmc/Checkpoint">000D29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D29</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000B92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B92</idno><idno type="wicri:Area/PubMed/Curation">000B92</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B92</idno><idno type="wicri:Area/PubMed/Checkpoint">000B92</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B92</idno><idno type="wicri:Area/Ncbi/Merge">007A11</idno><idno type="wicri:Area/Ncbi/Curation">007A11</idno><idno type="wicri:Area/Ncbi/Checkpoint">007A11</idno><idno type="wicri:doubleKey">1757-4676:2015:Nurmi H:vegf:c:is</idno><idno type="wicri:Area/Main/Merge">001636</idno><idno type="wicri:Area/Main/Curation">001634</idno><idno type="wicri:Area/Main/Exploration">001634</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption</title><author><name sortKey="Nurmi, Harri" sort="Nurmi, Harri" uniqKey="Nurmi H" first="Harri" last="Nurmi">Harri Nurmi</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author><author><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author><author><name sortKey="Zarkada, Georgia" sort="Zarkada, Georgia" uniqKey="Zarkada G" first="Georgia" last="Zarkada">Georgia Zarkada</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author><author><name sortKey="Robciuc, Marius R" sort="Robciuc, Marius R" uniqKey="Robciuc M" first="Marius R" last="Robciuc">Marius R. Robciuc</name><affiliation><nlm:aff id="au1"></nlm:aff></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation><nlm:aff id="au1"></nlm:aff><country>Finlande</country><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></analytic><series><title level="j">EMBO Molecular Medicine</title><idno type="ISSN">1757-4676</idno><idno type="eISSN">1757-4684</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Gene Deletion</term><term>Intestines (physiology)</term><term>Lipid Metabolism</term><term>Lymphatic Vessels (physiology)</term><term>Mice</term><term>Mice, Knockout</term><term>Vascular Endothelial Growth Factor C (genetics)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Délétion de gène</term><term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Intestins (physiologie)</term><term>Métabolisme des lipides</term><term>Souris</term><term>Souris knockout</term><term>Vaisseaux lymphatiques (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Intestins</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Intestines</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Deletion</term><term>Lipid Metabolism</term><term>Mice</term><term>Mice, Knockout</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Délétion de gène</term><term>Métabolisme des lipides</term><term>Souris</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Vascular endothelial growth factor C (VEGF-C) binding to its tyrosine kinase receptor VEGFR-3 drives lymphatic vessel growth during development and in pathological processes. Although the VEGF-C/VEGFR-3 pathway provides a target for treatment of cancer and lymphedema, the physiological functions of VEGF-C in adult vasculature are unknown. We show here that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine. Following <italic>Vegfc</italic> gene deletion in adult mice, the intestinal lymphatic vessels, including the lacteal vessels, underwent gradual atrophy, which was aggravated when also <italic>Vegfd</italic> was deleted. VEGF-C was expressed by a subset of smooth muscle cells adjacent to the lacteals in the villus and in the intestinal wall. The <italic>Vegfc-</italic>deleted mice showed defective lipid absorption and increased fecal excretion of dietary cholesterol and fatty acids. When fed a high-fat diet, the <italic>Vegfc</italic>-deficient mice were resistant to obesity and had improved glucose metabolism. Our findings indicate that the lymphangiogenic growth factors provide trophic and dynamic regulation of the intestinal lymphatic vasculature, which could be especially important in the dietary regulation of adiposity and cholesterol metabolism.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aspelund, A" uniqKey="Aspelund A">A Aspelund</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Antila, S" uniqKey="Antila S">S Antila</name></author><author><name sortKey="Nurmi, H" uniqKey="Nurmi H">H Nurmi</name></author><author><name sortKey="Leppanen, Vm" uniqKey="Leppanen V">VM Leppanen</name></author><author><name sortKey="Zarkada, G" uniqKey="Zarkada G">G Zarkada</name></author><author><name sortKey="Stanczuk, L" uniqKey="Stanczuk L">L 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Tv" uniqKey="Petrova T">TV Petrova</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Thurston, G" uniqKey="Thurston G">G Thurston</name></author><author><name sortKey="Mcdonald, Dm" uniqKey="Mcdonald D">DM McDonald</name></author><author><name sortKey="Achen, Mg" uniqKey="Achen M">MG Achen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventura, A" uniqKey="Ventura A">A Ventura</name></author><author><name sortKey="Kirsch, Dg" uniqKey="Kirsch D">DG Kirsch</name></author><author><name sortKey="Mclaughlin, Me" uniqKey="Mclaughlin M">ME McLaughlin</name></author><author><name sortKey="Tuveson, Da" uniqKey="Tuveson D">DA Tuveson</name></author><author><name sortKey="Grimm, J" uniqKey="Grimm J">J Grimm</name></author><author><name sortKey="Lintault, L" uniqKey="Lintault L">L Lintault</name></author><author><name sortKey="Newman, J" uniqKey="Newman J">J Newman</name></author><author><name 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Robciuc</name><name sortKey="Saharinen, Pipsa" sort="Saharinen, Pipsa" uniqKey="Saharinen P" first="Pipsa" last="Saharinen">Pipsa Saharinen</name><name sortKey="Zarkada, Georgia" sort="Zarkada, Georgia" uniqKey="Zarkada G" first="Georgia" last="Zarkada">Georgia Zarkada</name><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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